West, central myelinolysis in a patient with hyponatraemia. Mielinolisis central pontina tras sindrome neuroleptico. Mielinolisis pontina central e hiponatremia perioperatoria. Extrapontine myelinolysis epm is one of the complications occurring secondary to rapid correction of hyponatremia, and is, along with central pontine myelinolysis encompassed by the more recent term osmotic demyelination syndrome in the vast majority of cases it is associated with central pontine myelinolysis but it can also rarely occur as an isolated entity. Osmotic demyelination syndrome radiology reference. Central pontine myelinolysis cpm is the most severe neurological complication after liver transplantation and apparently is not. Pdf mielinolisis central pontina en trasplante hepatico. As such the condition is described in the osmotic demyelination syndrome article. Central pontine myelinolysis radiology reference article. Osmotic demyelination syndrome refers to acute demyelination seen in the setting of osmotic changes, typically with the rapid correction of hyponatremia. Mielinolisis extrapontina secundaria a hiponatremia por crisis.
Chronic alcoholism or rapid correction of hyponatremia was present in over 75% of cases. Acute neurological complications after liver transplantation with particular reference to intraoperative cerebral air embolus. Extrapontine myelinolysis radiology reference article. Central pontine myelinolysis after liver transplantation. Central pontine myelinolysis cpm is a neurological condition involving severe damage to the myelin sheath of nerve cells in the pons an area of the brainstem. Hospital general regional 110 imss university of arizona. Burns cause injuries that affect the integrity of the skin and can damage, among other systems, the neurological system, as some time after they take place, vasodilatation and marked cerebral edema with diffuse neuronal degeneration. Pdf central pontine myelinolysis is a demyelinating lesion in the basis pontis which in most cases is caused by a rapid correction of hyponatremia. It is predominately iatrogenic treatmentinduced, and is characterized by acute paralysis, dysphagia difficulty swallowing, dysarthria difficulty speaking, and other neurological symptoms. It is the more recent term replacing central pontine myelinolysis, recognizing that extrapontine structures can also be affected, previously known as extrapontine myelinolysis. Pdf mielinolisis pontina central e hiponatremia perioperatoria. Conventionally this has been perceived to lead to pontine glial cell swelling through osmosis and eventually to cell death. Antemortem computed tomography ct had been performed in nine, and ante or postmortem magnetic resonance mr imaging in 11. Central pontine myelinolysis cpm is now more commonly referred to as osmotic demyelination syndrome, which recognizes that the same phenomenon is also seen in other areas of the brain previously known as extrapontine myelinolysis.
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